" /> ETS Motif - CISMeF





Preferred Label : ETS Motif;

MeSH definition : A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.;

MeSH synonym : ETS Motifs; Helix-Turn-Helix, ETS-Type Domain Containing; Helix Turn Helix, ETS Type Domain Containing; ETS Domain; ETS Domains;

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Keyword's position in hierarchy(ies) : arborescence

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A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.

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10/05/2025


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