Type-2 Angiotensin II Receptor

Preferred Label : Type-2 Angiotensin II Receptor;

NCIt synonyms : AGTR2; Angiotensin Receptor 2; AT2; Angiotensin II Receptor, Type 2; Angiotensin II Type-2 Receptor; Angiotensin Receptor-2;

NCIt definition : Type-2 angiotensin II receptor (363 aa, 41 kDa) is encoded by the human AGTR2 gene. This protein is involved in signal transduction, apoptosis, and the regulation of blood pressure.;

NCIt note : Angiotensin Receptor 2, encoded by the AGTR2 gene, is an integral membrane protein and a member of G-protein coupled receptor family. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. (LocusLink);

NCI Metathesaurus CUI : CL1399770;

Details

Origin ID

C21388;

UMLS CUI

C5226670;

Currated CISMeF NLP mapping
- receptor, angiotensin, type 2 [MeSH Descriptor]
- receptor, angiotensin, type 2 [MeSH concept]
OMIM relation
- Angiotensin II receptor, type 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- AGTR2 protein, human [MeSH Supplementary Concept]
- receptor, angiotensin, type 2 [MeSH concept]
- receptor, angiotensin, type 2 [MeSH Descriptor]
gene_encodes_gene_product
- AGTR2 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Adrenal Gland [NCIt concept]
- Fallopian Tube [NCIt concept]
- Intestine [NCIt concept]
- Kidney [NCIt concept]
- Myometrium [NCIt concept]
gene_product_has_associated_anatomy
- Fetus [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Angiotensin-converting Enzyme 2 Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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