Epidermal Growth Factor

Preferred Label : Epidermal Growth Factor;

NCIt synonyms : Urogastrone; EGF; Anthelone U; Human Urinary Gastric Inhibitor;

NCIt definition : Epidermal growth factor (53 aa, 6 kDa) is encoded by the human EGF gene. This protein is involved in mitogenesis and magnesium reabsorption.;

Alternative definition : NCI-GLOSS: A protein made by many cells in the body and by some types of tumors. It causes cells to grow and differentiate (become more specialized). It is a type of growth factor and a type of cytokine.;

NCIt note : The active form of the growth factor, epidermal growth factor, is produced by two proteolytic cleavage events that remove 970 N-terminal amino acids and 184 amino acids from the C-terminus of pro-epidermal growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Codes from synonyms : CDR0000653114; CDR0000653115;

Details

Origin ID

C20425;

UMLS CUI

C0242275;

Automatic exact mappings (from CISMeF team)
- EGF Family of Proteins [MeSH Descriptor]
- Epidermal growth factor [OMIM gene]
- epidermal growth factor [ORDO Gene]
- epidermal growth factor [HGNC gene]
- epidermal growth factor receptor binding [GO term]
False automatic mappings
- Epidermal growth factor (substance) [SNOMED CT concept]
- epidermal growth factor (1-45) [MeSH concept]
- epidermal growth factor (1-45) [MeSH Supplementary Concept]
- epidermal growth factor (1-48) [MeSH concept]
- epidermal growth factor (1-48) [MeSH Supplementary Concept]
- epidermal growth factor (1-53) [MeSH concept]
- epidermal growth factor (1-53) [MeSH Supplementary Concept]
- epidermal growth factor (33-42) [MeSH concept]
- epidermal growth factor (33-42) [MeSH Supplementary Concept]
OMIM relation
- Epidermal growth factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Epidermal growth factor [LOINC component]
- Epidermal growth factor (substance) [SNOMED CT concept]
- epidermal growth factor [Substance BNPC]
- epidermal growth factor [SNOMED Notion]
- epidermal growth factor [MeSH concept]
- epidermal growth factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EGF Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Stabilization Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EGFR-Dependent Endothelin Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- ErbB3 Receptor Recycling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
- Vesicle Transport Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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