Preferred Label : ErbB3 Receptor Recycling Pathway;
NCIt related terms : Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling;
Alternative definition : BIOCARTA: The neuregulins comprise a subfamily of at least four epidermal growth factor
(EGF)-like growth factors that influence a variety of cellular events, including proliferation,
differentiation, migration, survival, and fate. The most thoroughly examined neuregulin,
neu differentiation factor NDF (AKA: neuregulin-1; NRG1; also heregulin, glial growth
factor, or acetylcholine receptor-inducing activity), has been shown to play essential
roles in the development of cardiac and neural tissues and also has been shown to
play a role in the postsynaptic development of the neuromuscular junction. The neuregulins
bind to ErbB3 or ErbB4 and can activate the ErbB2 receptor through a heterodimerization
mechanism. Heterodimers of ErbB3 and ErbB2, which has no direct ligand, are potent
in causing cell transformation. Controlled levels of signaling through ErbB and other
growth factor receptors are maintained by keeping a relatively limited amount of receptors
at the cell surface. Receptor overexpression can lead to disease states such as the
genesis or progression of tumors. Hence, mechanisms must exist for localizing and
maintaining a precise concentration of growth factor receptors at the site of signal
reception. ErbB2, ErbB3, and ErbB4 are somewhat unique among studied receptor tyrosine
kinases in that they exhibit impaired ligand-induced internalization, down-regulation,
and degradation. In fact, the rate of degradation is dependent on factors that appear
to act independent of ligand binding. Nrdp-1 (Neuregulin receptor degradation protein-1)
is one such protein. Ndrp-1 is an E3 ubiquitin ligase that tags ErbB3 for degradation
in non-lysosomal compartments. The cycling of ErbB1 is similar to that of EGF receptor
and is included for contrast. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_ErbB3Pathway;
Origin ID : C39069;
UMLS CUI : C1516954;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
