" /> Neuregulin-1 - CISMeF





Preferred Label : Neuregulin-1;

NCIt synonyms : Acetylcholine Receptor Inducing Activity; Neu Differentiation Factor; Sensory And Motor Neuron-Derived Factor; Breast Cancer Cell Differentiation Factor P45; ARIA; Glial Growth Factor; NRG1; Heregulin; Neuregulin-1 Protein; HRG; Sensory And Motor Neuron Derived Factor; Acetylcholine Receptor-Inducing Activity; Neuregulin 1;

NCIt definition : Neuregulin-1 (222 aa, 24 kDa) is encoded by the human NRG1 gene. This protein is involved in binding to receptors from the EGF receptor family of protein tyrosine kinases.;

NCIt note : The active form of the growth factor, neuregulin-1, is produced by two proteolytic cleavage events that remove the 19 N-terminal amino acid signal sequence and 399 amino acids from the C-terminus of pro-neuregulin-1, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt); Neuregulin-1 is a direct ligand for ERBB3 and ERBB4.;

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04/05/2025


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