Neuregulin-1 - CISMeF

Preferred Label : Neuregulin-1;

NCIt synonyms : Acetylcholine Receptor Inducing Activity; Neu Differentiation Factor; Sensory And Motor Neuron-Derived Factor; Breast Cancer Cell Differentiation Factor P45; ARIA; Glial Growth Factor; NRG1; Heregulin; Neuregulin-1 Protein; HRG; Sensory And Motor Neuron Derived Factor; Acetylcholine Receptor-Inducing Activity; Neuregulin 1;

NCIt definition : Neuregulin-1 (222 aa, 24 kDa) is encoded by the human NRG1 gene. This protein is involved in binding to receptors from the EGF receptor family of protein tyrosine kinases.;

NCIt note : The active form of the growth factor, neuregulin-1, is produced by two proteolytic cleavage events that remove the 19 N-terminal amino acid signal sequence and 399 amino acids from the C-terminus of pro-neuregulin-1, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt); Neuregulin-1 is a direct ligand for ERBB3 and ERBB4.;

Details

Origin ID

C18165;

UMLS CUI

C1437978;

Currated CISMeF NLP mapping
- Neuregulin-1 [MeSH Descriptor]
- Neuregulin-1 [MeSH concept]
- glial growth factor [MeSH concept]
- heregulin [MeSH concept]
- neu differentiation factor [MeSH concept]
OMIM relation
- Neuregulin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NRG1 protein, human [MeSH concept]
- NRG1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- NRG1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Breast [NCIt concept]
- Heart [NCIt concept]
- Nervous System [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- Agrin Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- ErbB3 Receptor Recycling Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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