ERBB3 wt Allele

Preferred Label : ERBB3 wt Allele;

NCIt synonyms : V-ERB-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Gene; EGF Receptor 3 Gene; HER3; Erb-B2 Receptor Tyrosine Kinase 3 wt Allele; p85-sErbB3; c-erbB-3; LCCS2; V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 Gene; ErbB-3; p180-ErbB3; MDA-BF-1; c-erbB3; erbB3-S; p45-sErbB3; V-ERB-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 Gene; FERLK; VSCN1;

NCIt definition : Human ERBB3 wild-type allele is located within 12q13 and is approximately 23 kb in length. This allele, which encodes receptor tyrosine-protein kinase erbB-3 protein, is involved in the regulation of celullar proliferation and differentiation. Amplification or overexpression of this gene, has been documented in several solid tumors and cancers, including prostate, bladder, and breast.;

GenBank Accession Number : NM_001982;

Détails

Origin ID

C51389;

UMLS CUI

C1704825;

OMIM relation
- Erb-b2 receptor tyrosine kinase 3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Malignant Breast Neoplasm [NCIt concept]
- Solid Neoplasm [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 12: 54760154-54782854 [NCIt concept]
gene_in_chromosomal_location
- 12q13 [NCIt concept]
gene_is_element_in_pathway
- ERBB2 Signaling Pathway [NCIt concept]
- ErbB3 Receptor Recycling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

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