" /> Selumetinib - CISMeF





Preferred Label : Selumetinib;

NCIt synonyms : MEK Inhibitor AZD6244;

NCIt related terms : AZD6244;

NCIt definition : An orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. AZD6244 blocks proteins needed for cell growth and may kill cancer cells. It is a type of protein kinase inhibitor.;

UNII : 6UH91I579U;

InChIKey : CYOHGALHFOKKQC-UHFFFAOYSA-N;

CAS number : 606143-52-6;

Molecule name : ARRY-142886; AZD 6244; AZD-6244;

Chemical formula : C17H15BrClFN4O3;

Codes from synonyms : CDR0000600473; CDR0000600474; 462;

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08/05/2025


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