Formyl Peptide Receptor 1 Signaling Pathway

Preferred Label : Formyl Peptide Receptor 1 Signaling Pathway;

NCIt related terms : fMLP induced chemokine gene expression in HMC-1 cells;

Alternative definition : BIOCARTA: Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other immune cells to the site of infection. The multisubunit enzyme NADPH oxidase, expressed by neutrophils, produces reactive oxygen species that are rapidly released in what is known as the respiratory burst. Activity of the NADPH oxidase is induced by fMLP receptor ligands, formylated peptides from bacteria. The fMLP receptor is a G-protein coupled receptor, FPR-1, that activates Map kinase pathways and phospholipase C. Phospholipase C activation releases IP3 and calcium, activating protein kinase C and also activating the transcription factor NFAT, which contributes to activation of chemokine genes. One of the components of the NADPH oxidase is p47phox. PKC activation phosphorylates p47phox to activate NADPH oxidase activity. Activation of Map kinase cascades leads to Erk1/Erk2 dependent p47phox phosphorylation as well as activation of the Elk-1 transcription factor and chemokine gene expression. Inhibition of p38 did not affect p47phox phosphorylation, indicating that p38 is not involved in Erk1/2 activation of the NADPH oxidase. Inhibition of p38 did inhibit NADPH oxidase though, indicating that other pathways contribute to activation of this enzyme. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_fMLPpathway;

Details

Origin ID

C39082;

UMLS CUI

C1517299;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Neutrophil Cytosol Factor 2 [NCIt concept]
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- fMet-Leu-Phe Receptor [NCIt concept]
pathway_has_gene_element
- ELK1 wt Allele [NCIt concept]
- FPR1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NCF2 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PIK3C2G wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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