Preferred Label : MEK 1/2 Inhibitor FCN-159;
NCIt synonyms : MEK Inhibitor FCN-159;
NCIt definition : An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K,
MAPK/ERK kinase, or MEK) 1 and 2, with potential antineoplastic activity. Upon administration,
MEK 1/2 Inhibitor FCN-159 selectively binds to and inhibits the activity of MEK1 and
MEK2, preventing the activation of MEK1/2-dependent effector proteins and transcription
factors, which may result in the inhibition of growth factor-mediated cell signaling
and tumor cell proliferation. MEK1/2 are dual-specificity threonine/tyrosine kinases
that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates
cell growth. This pathway is often dysregulated in a variety of tumor cell types through
BRAF, KRAS and NRAS mutations.;
Molecule name : FCN-159; FCN 159;
NCI Metathesaurus CUI : CL1406509;
Origin ID : C172382;
UMLS CUI : C5417912;
Semantic type(s)
- concept_is_in_subset
- has_target
