SRF Activation Pathway

Preferred Label : SRF Activation Pathway;

NCIt related terms : Role of MAL in Rho-Mediated Activation of SRF;

Alternative definition : BIOCARTA: Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77, and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission, as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2 , T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes, and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_malPathway;

Details

Origin ID

C39145;

UMLS CUI

C1519155;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cell Division Control Protein 42 Homolog [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- Hepatocyte Nuclear Factor 1-Alpha [NCIt concept]
- LIM Domain Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Serum Response Factor [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- ARHGEF1 wt Allele [NCIt concept]
- CDC42 wt Allele [NCIt concept]
- HNF1A wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- LIMK1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- SRF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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