" /> Trametinib - CISMeF





Preferred Label : Trametinib;

NCIt synonyms : MEK Inhibitor GSK1120212; N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide;

NCIt definition : An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK) 1 and 2, with potential antineoplastic activity. Upon oral administration, trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity serine/threonine and tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.;

UNII : 33E86K87QN;

InChIKey : LIRYPHYGHXZJBZ-UHFFFAOYSA-N;

CAS number : 871700-17-3;

Molecule name : GSK 1120212; JTP-74057; GSK-1120212; GSK 212; GSK-212; JTP 74057;

Chemical formula : C26H23FIN5O4;

Codes from synonyms : 508;

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07/05/2025


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