Preferred Label : MEK/RAF Molecular Glue SPYK04;
NCIt synonyms : MEK Inhibitor SPYK04; MEK1/2 Inhibitor SPYK04; MEK-RAF Molecular Glue SPYK04;
NCIt definition : An orally bioavailable mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase,
or MEK)/RAF molecular glue and dual MEK1 and 2 (MEK1/2) kinase inhibitor, with potential
antineoplastic activity. Upon oral administration, MEK/RAF molecular glue SPYK04 targets
and glues RAF with MEK, forming stable and inactive MEK-RAF complexes. This prevents
RAF-dependent phosphorylation and activation of MEK, thereby preventing MEK1/2-dependent
signaling and inhibiting tumor cell proliferation. Oncogenic mutations in RAF plays
a key role in the overactivation of the RAS-mitogen-activated protein kinase (MAPK)
pathway and drives tumor cell proliferation and survival. MEK1/2 are dual-specificity
threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK
pathway that regulates cell growth. This pathway is often dysregulated in a variety
of tumor cell types.;
Molecule name : SPYK 04; SPYK-04;
Origin ID : C217664;
concept_is_in_subset
- has_target
