Preferred Label : MEK1/2 Inhibitor ABM-168;
NCIt synonyms : MEK 1/2 Inhibitor ABM-168;
NCIt definition : An orally bioavailable, brain-penetrant, allosteric inhibitor of mitogen-activated
protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2, with potential antineoplastic
activity. Upon oral administration, MEK1/2 inhibitor ABM-168 selectively binds to
and inhibits the activity of MEK1 and MEK2, preventing the activation of MEK1/2-dependent
effector proteins and transcription factors, which may result in the inhibition of
growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 are dual-specificity
threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK
pathway that regulates cell growth. This pathway is often dysregulated in a variety
of tumor cell types through BRAF, KRAS and NRAS mutations. ABM-168 is able to cross
the blood-brain barrier (BBB).;
Molecule name : ABM 168; ABM-168;
NCI Metathesaurus CUI : CL1906553;
Origin ID : C199650;
UMLS CUI : C5854449;
Semantic type(s)
- concept_is_in_subset
- has_target
