Binimetinib - CISMeF

Preferred Label : Binimetinib;

NCIt definition : An orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.;

UNII : 181R97MR71;

InChIKey : ACWZRVQXLIRSDF-UHFFFAOYSA-N;

CAS number : 606143-89-9;

Drug name : Mektovi;

Molecule name : ARRY-438162; ARRY-162; MEK-162; ARRY 162; ARRY 438162; MEK 162;

Codes from synonyms : 71;

Details

Origin ID

C84865;

UMLS CUI

C3899947;

Automatic exact mappings (from CISMeF team)
- MEK162 [MeSH concept]
- binimetinib [ATC Code]
Currated CISMeF NLP mapping
- Binimetinib [ICD-11 Extension code]
- Binimetinib [SMS substance]
- Binimetinib (substance) [SNOMED CT concept]
- binimetinib [MeSH Supplementary Concept]
- binimetinib [MeSH concept]
See also inter- (CISMeF)
- Mektovi [MeSH concept]
- Product containing binimetinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Binimetinib (substance) [SNOMED CT concept]
- Product containing binimetinib (medicinal product) [SNOMED CT concept]
- binimetinib [MeSH Supplementary Concept]
- binimetinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Binimetinib Regimen [NCIt concept]
- Binimetinib/Encorafenib Regimen [NCIt concept]
- Binimetinib/Imatinib Regimen [NCIt concept]
- Encorafenib-Binimetinib-Cetuximab Regimen [NCIt concept]
- Encorafenib-Binimetinib-Panitumumab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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