Preferred Label : MEK 1/2 Inhibitor AS703988/MSC2015103B;
NCIt definition : An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase
kinase (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2 with potential antineoplastic activity.
MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity
of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription
factors, which may result in the inhibition of growth factor-mediated cell signaling
and tumor cell proliferation. MEK1/2 are dual-specificity threonine/tyrosine kinases
that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates
cell growth and are often upregulated in a variety of tumor cell types.;
Molecule name : AS703988/MSC2015103B; MSC2015103B; AS703988;
NCI Metathesaurus CUI : CL432851;
Origin ID : C98832;
UMLS CUI : C3274460;
Semantic type(s)
- concept_is_in_subset
- has_target
