Preferred Label : MEK Inhibitor IMM-1-104;
NCIt synonyms : MEK1/2 Inhibitor IMM-1-104;
NCIt definition : An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K;
MAPK/ERK kinase; MEK) 1 and MEK2, with potential antineoplastic activity. Upon oral
administration, MEK inhibitor IMM-1-104 selectively binds to and inhibits the activity
of MEK1/2. This prevents the activation of MEK1/2-dependent effector proteins and
transcription factors, which may result in the inhibition of growth factor-mediated
cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity
threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK
pathway and are often upregulated in a variety of tumor cell types.;
Molecule name : IMM-1-104; IMM 1-104;
NCI Metathesaurus CUI : CL1912843;
Origin ID : C192810;
UMLS CUI : C5785433;
Semantic type(s)
- concept_is_in_subset
- has_target
