NCIt definition : An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein
kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. Upon
administration, mirdametinib selectively binds to and inhibits MEK, which may result
in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition
of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a
key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated
in human tumors.;
UNII : 86K0J5AK6M;
CAS number : 391210-10-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 391210-10-9
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