Estrogen Receptor Family

Preferred Label : Estrogen Receptor Family;

NCIt synonyms : ER; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A; NR3A; ER Family; Estrogen Receptor Family Protein; Estrogen Receptor;

NCIt definition : Widely expressed human Estrogen Receptors (NR3 Family) are cytoplasmic hormone-activated receptors that act as nuclear transcription factors composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. Binding to DNA as a homo- or heterodimer, ESR interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. DNA-binding is lost in the absence of ligand. (NCI);

NCI Metathesaurus CUI : CL1798376;

Details

Origin ID

C17069;

UMLS CUI

C5441529;

Currated CISMeF NLP mapping
- Estradiol receptor (substance) [Inactive SNOMED CT concept]
- Estrogen receptor [LOINC component]
- estrogen receptor site [SNOMED Notion]
- receptors, estradiol [MeSH Descriptor]
- receptors, estradiol [MeSH concept]
- receptors, estrogen [MeSH Descriptor]
- receptors, estrogen [MeSH concept]
False automatic mappings
- Amelogenesis imperfecta, type ig [OMIM Phenotype]
- Estrogen receptor (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Estrogen receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Estrogen receptor [LOINC component]
- Estrogen receptor (substance) [SNOMED CT concept]
- estrogen receptor site [SNOMED Notion]
- receptors, estrogen [MeSH concept]
- receptors, estrogen [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
- Tumor Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- F-18 16 Alpha-Fluoroestradiol [NCIt concept]

Keyword's position in hierarchy(ies) :

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