" /> Estrogen Receptor Family - CISMeF





Preferred Label : Estrogen Receptor Family;

NCIt synonyms : ER; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A; NR3A; ER Family; Estrogen Receptor Family Protein; Estrogen Receptor;

NCIt definition : Widely expressed human Estrogen Receptors (NR3 Family) are cytoplasmic hormone-activated receptors that act as nuclear transcription factors composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. Binding to DNA as a homo- or heterodimer, ESR interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. DNA-binding is lost in the absence of ligand. (NCI);

NCI Metathesaurus CUI : CL1798376;

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25/07/2025


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