Estrogen Receptor Beta

Preferred Label : Estrogen Receptor Beta;

NCIt synonyms : ER-Beta; ESR2; Nuclear Receptor Subfamily 3 Group A Member 2; Estrogen Receptor 2; NR3A2;

NCIt definition : Estrogen receptor beta (530 aa, 59 kDa) is encoded by the human ESR2 gene. This protein is involved in the modulation of transcription of estrogen-responsive genes.;

NCIt note : ESR2 binds estrogens with an affinity similar to ESR1 and transduces extracellular hormone signals into transcriptional responses by binding ERE DNA as a homodimer or as a heterodimer with ESR1, NCOA3, NCOA5, or NCOA6 coactivators and activating target gene expression in an estrogen-dependent manner. Lacking ligand binding ability and ERE binding activity, isoform Beta-2/CX preferentially forms a heterodimer with ESR1 and inhibits ligand-dependent DNA-binding and transactivation.;

Details

Origin ID

C38364;

UMLS CUI

C1523984;

Currated CISMeF NLP mapping
- estrogen receptor 2 [MeSH concept]
- estrogen receptor beta [MeSH Descriptor]
- estrogen receptor beta [MeSH concept]
OMIM relation
- Estrogen receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ESR2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Lasofoxifene [NCIt concept]
- S-equol [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients