Preferred Label : S-equol;
NCIt synonyms : 2H-1-benzopyran-7-ol, 3,4-Dihydro-3-(4-hydroxyphenyl)-, (3S)-; (3S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol; (-)-Equol;
NCIt related terms : EQUOL;
NCIt definition : An orally bioavailable, non-steroidal estrogen naturally produced by the metabolism
of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective
and estrogen receptor (ER) modulating activities. S-equol preferentially binds to
and activates the beta isoform of ER in certain target tissues, while having an antagonistic
effect in other tissues. This modulates the expression of ER-responsive genes in a
tissue-specific manner. This agent may increase bone mineral density, affect vasomotor
symptoms, and may decrease the proliferation rate of susceptible cancer cells. In
addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis.
S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation
of androgen-driven prostate cancer. S-equol is the biologically active enantiomer
while R-equol is essentially inactive and has a weak affinity for alpha-ER.;
UNII : 2T6D2HPX7Q;
InChIKey : ADFCQWZHKCXPAJ-GFCCVEGCSA-N;
CAS number : 531-95-3;
Origin ID : C120313;
UMLS CUI : C3896945;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_target
