Liver X Receptor-Like Family

Preferred Label : Liver X Receptor-Like Family;

NCIt synonyms : Nuclear Receptor Subfamily 1 Group H; NR1H; LXR Family; LXR;

NCIt definition : A nuclear receptor family that binds oxysterols or bile acids and, after forming a heterodimer with a member of the retinoid X receptor (RXR) family, modulates the expression of genes that are involved in cholesterol, fatty acid, and glucose homeostasis. The members of this family include oxysterols receptor LXR-alpha (NR1H3), oxysterols receptor LXR-beta (NR1H2) and bile acid receptor (NR1H4).;

NCI Metathesaurus CUI : CL508903;

Details

Origin ID

C128275;

UMLS CUI

C4288814;

Automatic exact mappings (from CISMeF team)
- Nuclear receptor subfamily 1, group H, member 3 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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