Nuclear Receptor Subfamily 1 Group I Member 2

Preferred Label : Nuclear Receptor Subfamily 1 Group I Member 2;

NCIt synonyms : Pregnane X Nuclear Receptor; Pregnane X Receptor; Orphan Nuclear Receptor PXR; Steroid and Xenobiotic Receptor; Orphan Nuclear Receptor PAR1; NR1I2;

NCIt definition : Nuclear receptor subfamily 1 group I member 2 (434 aa, 50 kDa) is encoded by the human NR1I2 gene. This protein is involved in the metabolism of xenobiotics and steroids.;

NCIt note : Ligands for nuclear receptor subfamily 1 group I member 2 include dexamethasone, the antibiotic rifampicin, various plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones, and endogenous steroids, such as pregnenolone and progesterone. (UniProt); Exposure to certain xenobiotics and steroids induces nuclear receptor subfamily 1 group I member 2 to bind to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. (UniProt);

Details

Origin ID

C127844;

UMLS CUI

C1744349;

Automatic exact mappings (from CISMeF team)
- Nuclear receptor subfamily 1, group I, member 2 [OMIM gene]
- Pregnane X Receptor [MeSH Descriptor]
- nuclear receptor subfamily 1 group I member 2 [HGNC gene]
- pregnane X receptor [MeSH concept]
OMIM relation
- Nuclear receptor subfamily 1, group I, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- NR1I2 protein, human [MeSH concept]
- NR1I2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NR1I2 Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Detoxification [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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