Androgen Receptor Splice Variant 3

Preferred Label : Androgen Receptor Splice Variant 3;

NCIt synonyms : Androgen Receptor Splice Variant 7; AR-v7; AR3;

NCIt definition : Androgen receptor protein that is comprised of the amino acids encoded by exons 1-3 and those encoded by cryptic exon 3 (CE3) of the human AR gene. This variant protein contains nuclear receptor transcriptional activation and DNA binding domains and is missing the hinge region and the nuclear receptor ligand binding and activation function-2 domains. Expression of this variant is associated with both a constitutively active, gain-of-function phenotype and prostate cancer.;

NCI Metathesaurus CUI : CL509601;

PubMed : 21778211;

Details

Origin ID

C128292;

UMLS CUI

C4283899;

OMIM relation
- Androgen receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Gene Expression [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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