Nuclear Receptor Subfamily 0 Group B Member 2

Preferred Label : Nuclear Receptor Subfamily 0 Group B Member 2;

NCIt synonyms : NR0B2; Orphan Nuclear Receptor-SHP; SHP1; SHP; Short Heterodimer Partner; Orphan Nuclear Receptor SHP; Small Heterodimer Partner;

NCIt definition : Nuclear receptor subfamily 0 group B member 2 (257 aa, 28 kDa) is encoded by the human NR0B2 gene. This protein plays a role in the negative regulation of transcription.;

NCIt note : Orphan Nuclear Receptor SHP, contains a putative ligand-binding domain and a dimerization domain, but lacks a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression.;

Details

Origin ID

C34000;

UMLS CUI

C1335142;

Currated CISMeF NLP mapping
- nuclear receptor subfamily 0, group B, member 2 [MeSH concept]
- nuclear receptor subfamily 0, group B, member 2 [MeSH Supplementary Concept]
OMIM relation
- Nuclear receptor subfamily 0, group b, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- NR0B2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NR0B2 Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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