Retinoic Acid Receptor Beta

Preferred Label : Retinoic Acid Receptor Beta;

NCIt synonyms : HBV-Activated Protein; RAR-Epsilon; Retinoic Acid Receptor Beta 2; Retinoic Acid Receptor Beta 4; Hepatitis B Virus Activated Protein; RARB; RAR-Beta; Nuclear Receptor Subfamily 1 Group B Member 2; NR1B2;

NCIt definition : Retinoic acid receptor beta (455 aa, 50 kDa) is encoded by the human RARB gene. This protein plays a role in the modulation of retinoic acid-dependent gene expression.;

NCIt note : Alternative isoforms of Retinoic Acid Receptor Beta (1-4) are composed of three domains: an N-terminal modulating domain, a central DNA-binding domain, and a C-terminal ligand-binding domain. RARB controls embryonic morphogenesis, cell proliferation, and differentiation by directly regulating gene transcription. RARB appears to limit growth of many cell types.;

Details

Origin ID

C29764;

UMLS CUI

C1999666;

Currated CISMeF NLP mapping
- retinoic acid receptor beta [MeSH concept]
- retinoic acid receptor beta [MeSH Supplementary Concept]
OMIM relation
- Retinoic acid receptor, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- RARB protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- RARB Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Morphogenesis [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Retinoic Acid Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Tamibarotene [NCIt concept]

Keyword's position in hierarchy(ies) :

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