Preferred Label : Tamibarotene;
NCIt synonyms : Retinobenzoic Acid; 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl); N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic Acid; Benzoic Acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-Tetramethyl-2-naphthalenyl)amino)carbonyl)-;
NCIt definition : An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid
(ATRA) resistance, with potential antineoplastic activity. As a specific retinoic
acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more
potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic
leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid
binding protein (CRABP), tamibarotene may show sustained plasma levels compared to
ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part,
due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor
in the dermal epithelium.;
UNII : 08V52GZ3H9;
InChIKey : MUTNCGKQJGXKEM-UHFFFAOYSA-N;
CAS number : 94497-51-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 94497-51-5
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G-SRS /a ;
Molecule name : Am-80; INNO-507; Z-208; SY-1425; TM-411; TOS-80T;
Chemical formula : C22H25NO3;
NSC code : 608000;
ChEBI ID : CHEBI:32181;
Codes from synonyms : 478;
Origin ID : C71025;
UMLS CUI : C1567753;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
