Retinoic Acid Binding

Preferred Label : Retinoic Acid Binding;

NCIt definition : Retinoic Acid Binding consists of a biophysical interaction between retinoic acid (ligand) and a biological molecule, such as specific steroid receptor-like transcriptional regulator proteins containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal ligand-binding domain. The ligand-activated receptor complexes selectively bind as homodimers or heterodimers (with other steroid family receptors) to DNA response elements in target gene promoters, enhance transcriptional activity with coactivators, and mediate tissue growth and differentiation in embryogenesis, organogenesis, limb development, bone growth, and maintenance of normal epithelia.;

Details

Origin ID

C26052;

UMLS CUI

C1514916;

Currated CISMeF NLP mapping
- retinoic acid binding [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- retinoic acid binding [GO term]
biological_process_involves_gene_product
- Cellular Retinoic Acid Binding Protein [NCIt concept]
- Cellular Retinoic Acid-Binding Protein 1 [NCIt concept]
- Cellular Retinoic Acid-Binding Protein 2 [NCIt concept]
- Retinoic Acid Receptor Alpha [NCIt concept]
- Retinoic Acid Receptor Alpha Isoform Alpha-2 [NCIt concept]
- Retinoic Acid Receptor Beta [NCIt concept]
- Retinoic Acid Receptor Gamma [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
- Biochemical Reaction [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Signal Transduction [NCIt concept]
process_involves_gene
- CRABP1 Gene [NCIt concept]
- CRABP1 wt Allele [NCIt concept]
- RARA Gene [NCIt concept]
- RARA wt Allele [NCIt concept]
- RARB Gene [NCIt concept]
- RARB wt Allele [NCIt concept]
- RARG Gene [NCIt concept]
- RARG wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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