Steroidogenic Factor 1

Preferred Label : Steroidogenic Factor 1;

NCIt synonyms : STF-1; Steroid Hormone Receptor Ad4BP; Fushi Tarazu Factor Homolog 1; Adrenal 4-Binding Protein; Nuclear Receptor Subfamily 5 Group A Member 1; SF-1; NR5A1; Adrenal 4 Binding Protein; Steroidogenic Factor-1; Ad4-Binding Protein; Ad4BP;

NCIt definition : Steroidogenic factor 1 (461 aa, 52 kDa) is encoded by the human NR5A1 gene. This protein plays a role in the activation of transcription of steroidogenic genes.;

NCIt note : Steroidogenic factor 1 binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. It also binds to the consensus sequences 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' in a number of gene promoter regions, including those regulating the expression of the AMH, NR0B1 and STAR genes. (UniProt);

Détails

Origin ID

C75873;

UMLS CUI

C1569965;

OMIM relation
- Nuclear receptor subfamily 5, group a, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NR5A1 protein, human [MeSH concept]
- NR5A1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- Pediatric Oncology Target Cell Lineage Determinant Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NR5A1 Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Sexual Maturation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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