Preferred Label : FGF4 wt Allele;
NCIt synonyms : KS3; K-FGF; Fibroblast Growth Factor 4 (Heparin Secretory Transforming Protein 1, Kaposi Sarcoma
Oncogene) Gene; HST-1; HSTF1; KFGF; HST; Fibroblast Growth Factor 4 wt Allele; HBGF-4; Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene; Kaposi Sarcoma Oncogene Gene;
NCIt definition : Human FGF4 wild-type allele is located in the vicinity of 11q13.3 and is approximately
2 kb in length. This allele, which encodes fibroblast growth factor 4 protein, plays
a role in cell growth.;
NCIt note : FGF4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) gene, located
at 11q13, encodes fibroblast growth factor 4 protein. This gene exhibits oncogenic
transforming activity and is amplified in a number of types of human tumors. The gene
was originally identified by its oncogenic transforming activity. Further, FGF4 and
FGF3, another oncogenic growth factor, are co-amplified in various kinds of human
tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and
limb development through the sonic hedgehog (SHH) signaling pathway.;
GenBank Accession Number : NM_002007;
Origin ID : C51498;
UMLS CUI : C1705579;
Automatic exact mappings (from CISMeF team)
- KS 3 [MeSH Supplementary Concept]
OMIM relation
Semantic type(s)
concept_is_in_subset
gene_found_in_organism
gene_has_physical_location
gene_in_chromosomal_location
gene_is_element_in_pathway
gene_plays_role_in_process