Brain-Derived Neurotrophic Factor

Preferred Label : Brain-Derived Neurotrophic Factor;

NCIt synonyms : Abrineurin; BDNF; Brain Derived Neurotrophic Factor;

NCIt definition : Brain-derived neurotrophic factor (247 aa, 28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the nervous system and neuronal survival.;

NCIt note : The active form of brain-derived neurotrophic factor is produced by proteolytic cleaves that remove 128 N-terminal residues from the full length precursor protein. (UniProt);

Details

Origin ID

C20445;

UMLS CUI

C3486709;

Currated CISMeF NLP mapping
- Brain-Derived neurotrophic factor [MeSH concept]
- Brain-derived neurotrophic factor [LOINC component]
- brain-derived neurotrophic factor [MeSH Descriptor]
OMIM relation
- Brain-derived neurotrophic factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BDNF protein, human [MeSH concept]
- BDNF protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BDNF Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Neurotrophic Factor [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_is_element_in_pathway
- Huntington's Disease Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Neurotrophic Factor-Mediated NTRK1 Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Neural Development [NCIt concept]
- Receptor Signaling [NCIt concept]
- Stress Response Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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