MAP Kinase-Activated Protein Kinase 5

Preferred Label : MAP Kinase-Activated Protein Kinase 5;

NCIt synonyms : PRAK; MAPKAPK-5; MK5; EC 2.7.11.1; p38-Regulated/Activated Protein Kinase; MAPKAP-K5; MAPKAP Kinase 5; p38-Regulated/Activated Kinase; MAPK-Activated Protein Kinase 5; MK-5;

NCIt definition : MAP kinase-activated protein kinase 5 (473 aa, 54 kDa) is encoded by the human MAPKAPK5 gene. This protein is involved in serine/threonine phosphorylation, tumor growth suppression and signaling regulation.;

NCIt note : MAP kinase-activated protein kinase 5 translocates to the cytoplasm following phosphorylation and activation. (UniProt);

Details

Origin ID

C113083;

UMLS CUI

C1431394;

Automatic exact mappings (from CISMeF team)
- MAP-kinase-activated kinase 5 [MeSH Supplementary Concept]
- Mitogen-activated protein kinase-activated protein kinase 5 [OMIM gene]
OMIM relation
- Mitogen-activated protein kinase-activated protein kinase 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAPKAPK5 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAPKAPK5 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- MAPK Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Induction of Cell Senescence [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Translational Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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