map kinase signaling system

Preferred Label : map kinase signaling system;

MeSH definition : An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.; An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.;

CISMeF synonym : cascades, map kinase; kinase modules, map; kinase cascades, map; kinase module, map; modules, map kinase;

MeSH hyponym : p38 kinase pathway; MAP kinase cascade; MEK-ERK pathway; ERK signal tranduction pathway; JNK pathway; Kinase Pathway, p38; Kinase Pathways, p38; Pathway, p38 Kinase; Pathways, p38 Kinase; p38 Kinase Pathways; p38 Kinase Signaling Pathway; Cascade, MAP Kinase; Kinase Cascade, MAP; MAP Kinase Cascades; MAP Kinase Modules; MAP Kinase Module; Module, MAP Kinase; MAP Kinase Signaling Cascades; MEK ERK Pathway; MEK-ERK Pathways; Pathway, MEK-ERK; Pathways, MEK-ERK; ERK Pathway; ERK Pathways; Pathway, ERK; Pathways, ERK; JNK Pathways; Pathway, JNK; Pathways, JNK; JNK Signaling Pathway; JNK Signaling Pathways; Pathway, JNK Signaling; Pathways, JNK Signaling; Signaling Pathway, JNK; Signaling Pathways, JNK; MAP Kinase Signaling Cascade;

Related MeSH term : ERK1-2 pathway; MAP kinase signaling pathways; ERK1 2 Pathway; ERK1-2 Pathways; Pathway, ERK1-2; Pathways, ERK1-2; ERK1 and ERK2 Pathway; MAP Kinase Signaling Pathway;

Details

Origin ID

D020935;

UMLS CUI

C0752321;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- MAPK Signaling Pathway [NCIt concept]
- MAPK cascade [GO term]
- stress-activated protein kinase signaling cascade [GO term]
Indexing information
- RPS6KA1 protein, human [MeSH Supplementary Concept]
- RPS6KA4 protein, human [MeSH Supplementary Concept]
- Rps6ka4 protein, mouse [MeSH Supplementary Concept]
- SPRED2 protein, human [MeSH Supplementary Concept]
- SPRED3 protein, human [MeSH Supplementary Concept]
- Spred-3 protein, mouse [MeSH Supplementary Concept]
- Spred1 protein, mouse [MeSH Supplementary Concept]
- Spred1 protein, rat [MeSH Supplementary Concept]
- Spred2 protein, mouse [MeSH Supplementary Concept]
- TAB1 protein, MAPKKK activator, vertebrate [MeSH Supplementary Concept]
- TAB1 protein, xenopus [MeSH Supplementary Concept]
- Tab1 protein, mouse [MeSH Supplementary Concept]
- mitogen and stress-activated protein kinase 1 [MeSH Supplementary Concept]
- ribosomal protein S6 kinase, 90kDa, polypeptide 3 [MeSH Supplementary Concept]
Record concept(s)
- ERK signal tranduction pathway [MeSH concept]
- ERK1-2 pathway [MeSH concept]
- JNK pathway [MeSH concept]
- MAP kinase cascade [MeSH concept]
- MAP kinase signaling pathways [MeSH concept]
- MAP kinase signaling system [MeSH concept]
- MEK-ERK pathway [MeSH concept]
- p38 kinase pathway [MeSH concept]
See also
- MAP kinase kinase kinases [MeSH Descriptor]
- Mitogen-Activated protein kinase kinases [MeSH Descriptor]
- Mitogen-Activated protein kinases [MeSH Descriptor]
Semantic type(s)
- Molecular Function [UMLS semantic type]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

https://rmlg.uliege.be/article/2480
2013
false
true
false
Belgium
French
journal article
melanoma
melanoma
proto-oncogene proteins b-raf
Mitogen-Activated protein kinase kinases
skin neoplasms
melanoma, cutaneous malignant
Tyrosine Kinase Inhibitors
map kinase signaling system
medical oncology
melanoma

---