" /> PDGFB wt Allele - CISMeF





Preferred Label : PDGFB wt Allele;

NCIt synonyms : PDGF2; SSV; v-SIS Homolog; SIS Gene; SIS; Platelet Derived Growth Factor Subunit B wt Allele; c-sis; PDGF-2; Oncogene SIS Gene; LL22NC03-10C3.2; Simian Sarcoma Viral Oncogene Homolog Gene; Platelet-Derived Growth Factor, Beta Polypeptide (Oncogene SIS) Gene; IBGC5; Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (v-sis) Oncogene Homolog) Gene; Platelet-Derived Growth Factor Beta Polypeptide Gene;

NCIt definition : Human PDGFB wild-type allele is located in the vicinity of 22q13.1 and is approximately 22 kb in length. This allele, which encodes platelet-derived growth factor subunit B protein, is involved in mitogenesis for mesenchymal cells. Mutations in the gene produce allelic variants that are associated with meningioma.;

NCIt note : Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP.;

GenBank Accession Number : NM_002608;

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29/07/2025


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