Preferred Label : DBPB Transcriptional Activation Pathway;
NCIt synonyms : YBX1 Transcriptional Activation Pathway;
NCIt related terms : Transcriptional activation of dbpb from mRNA;
Alternative definition : BIOCARTA: Endothelial cells respond to treatment with the protease thrombin with increased
secretion of the PDGF B-chain. This activation occurs at the transcriptional level
and a thrombin response element was identified in the promoter of the PDGF B-chain
gene. A transcription factor called the DNA-binding protein B (dbpB) mediates the
activation of PDGF B-chain transcription in response to thrombin treatment. DbpB is
a member of the Y box family of transcription factors and binds to both RNA and DNA.
In the absence of thrombin, endothelial cells contain a 50 kD form of dbpB that binds
RNA in the cytoplasm and may play a role as a chaperone for mRNA. The 50 kD version
of dbpB also binds DNA to regulate genes containing Y box elements in their promoters.
Thrombin activation results in the cleavage of dbpB to a 30 kD form. The proteolytic
cleavage releases dbpB from RNA in the nucleus, allowing it to enter the nucleus and
binds to a regulatory element distinct from the site recognized by the full length
50 kD dbpB. The genes activated by cleaved dbpB include the PDGF B chain. Dephosphorylation
of dbpB also regulates nuclear entry and transcriptional activation. RNA digestion
in vitro can release dbpB in its active form, suggesting that the protease responsible
for dbpB may be closely associated in a complex. Identification of the protease that
cleaves dbpB, the mechanisms of phosphorylation and dephosphorylation, and elucidation
of the signaling path by which thrombin induces dbpB will provide greater understanding
of this novel signaling pathway. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_dbpbPathway;
Origin ID : C39046;
UMLS CUI : C1511651;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
