Platelet-Derived Growth Factor Subunit B

Preferred Label : Platelet-Derived Growth Factor Subunit B;

NCIt synonyms : PDGF, B Chain; Platelet-Derived Growth Factor Beta; PDGF-2; SIS Gene Product; PDGFB; Platelet-Derived Growth Factor, B Chain; PDGF B-Chain; Platelet-Derived Growth Factor Beta Polypeptide; Platelet-Derived Growth Factor, Beta Polypeptide; Platelet Derived Growth Factor Beta Chain; Platelet-Derived Growth Factor B Chain; Platelet-Derived Growth Factor 2; Proto-Oncogene c-Sis; PDGF Subunit B;

NCIt definition : Platelet-derived growth factor subunit B (241 aa, 27 kDa) is encoded by the human PDGFB gene. This protein is involved in the regulation of embryonic development, cell proliferation, cell migration, cell survival and chemotaxis.;

NCIt note : Platelet-derived growth factor subunit B can exist as either antiparallel disulfide-linked homodimers or as heterodimers with platelet-derived growth factor subunit A. A-A, B-B, and A-B, dimers can bind to PDGF receptors and elicit a variety of cellular responses.;

Details

Origin ID

C20449;

UMLS CUI

C3887785;

OMIM relation
- Platelet-derived growth factor, beta polypeptide [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- PDGFB Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Platelet-Derived Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- DBPB Transcriptional Activation Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 1 Signaling Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 3 Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Platelet-Derived Growth Factor-AB [NCIt concept]
- Platelet-Derived Growth Factor-BB [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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