Platelet-Derived Growth Factor-AB

Preferred Label : Platelet-Derived Growth Factor-AB;

NCIt synonyms : PDGF-AB;

NCIt definition : A disulfide-linked heterodimeric protein complex comprised of one platelet-derived growth factor subunit A and one platelet-derived growth factor subunit B. This dimeric growth factor binds to a heterodimeric receptor comprised of one platelet-derived growth factor receptor alpha and one platelet-derived growth factor receptor beta. Ligand binding activates the intrinsic tyrosine-protein kinase activity of the receptor complex and initiates signal transduction pathways.;

Details

Origin ID

C128286;

UMLS CUI

C0381163;

Automatic exact mappings (from CISMeF team)
- platelet-derived growth factor AB [MeSH concept]
- platelet-derived growth factor AB [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- platelet-derived growth factor AB [MeSH Supplementary Concept]
- platelet-derived growth factor AB [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Platelet-Derived Growth Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Receptor Signaling [NCIt concept]
has_gene_product_element
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Platelet-Derived Growth Factor Subunit B [NCIt concept]
related_to_genetic_biomarker
- PDGFA Gene [NCIt concept]
- PDGFB Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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