Platelet-Derived Growth Factor Subunit A

Preferred Label : Platelet-Derived Growth Factor Subunit A;

NCIt synonyms : Platelet-Derived Growth Factor Alpha Polypeptide; PDGFA; PDGF-1; PDGF A-Chain; Platelet-Derived Growth Factor A Chain; Platelet-Derived Growth Factor Alpha Chain; Platelet-Derived Growth Factor, A Chain; PDGF Subunit A; Platelet-Derived Growth Factor Alpha;

NCIt definition : Platelet-derived growth factor subunit A (211 aa, 24 kDa) is encoded by the human PDGFA gene. This protein plays a role in the regulation of chemotaxis, cell migration, cell survival, cell proliferation, and embryonic development.;

NCIt note : Platelet-derived growth factor subunit A can exist as either antiparallel disulfide-linked homodimers or as heterodimers with platelet-derived growth factor subunit B. A-A, B-B, and A-B, dimers can bind to PDGF receptors and elicit a variety of cellular responses.;

Details

Origin ID

C30162;

UMLS CUI

C1335430;

Automatic exact mappings (from CISMeF team)
- Platelet-derived growth factor, alpha polypeptide [OMIM gene]
- platelet derived growth factor subunit A [HGNC gene]
- platelet-derived growth factor A [MeSH Supplementary Concept]
OMIM relation
- Platelet-derived growth factor, alpha polypeptide [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- PDGFA protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- PDGFA Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Platelet-Derived Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Cell Migration Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
gene_product_is_physical_part_of
- Platelet-Derived Growth Factor-AA [NCIt concept]
- Platelet-Derived Growth Factor-AB [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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