RASGRP1 wt Allele

Preferred Label : RASGRP1 wt Allele;

NCIt synonyms : MGC129998; CALDAG-GEFII; hRasGRP1; MGC129999; CALDAG-GEFI; RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) wt Allele; Guanine Nucleotide Exchange Factor, Calcium- and DAG-Regulated, Rap1A Gene; V; RASGRP;

NCIt definition : Human RASGRP1 wild-type allele is located in the vicinity of 15q14 and is approximately 77 kb in length. This allele, which encodes RAS guanyl-releasing protein 1, is involved in the modulation of small GTPase activation through its guanine nucleotide exchange activity. Mutation of the gene is associated with systemic lupus erythematosus.;

NCIt note : Cytogenetic abnormalities or mutations in the RASGRP1 gene may be associated with acute myeloid leukemia. (Nature Genetics. 2011; 43: 470-475.);

GenBank Accession Number : AF106071;

Details

Origin ID

C97227;

UMLS CUI

C3273289;

OMIM relation
- Ras guanyl nucleotide-releasing protein 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 15q14 [NCIt concept]
gene_is_element_in_pathway
- MAPK Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_plays_role_in_process
- B-Cell Differentiation [NCIt concept]
- Platelet Activation [NCIt concept]
- Signal Transduction [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- T-Cell Differentiation [NCIt concept]

Keyword's position in hierarchy(ies) :

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