FGF6 wt Allele

Preferred Label : FGF6 wt Allele;

NCIt synonyms : HST-2; HST2; Fibroblast Growth Factor 6 wt Allele; HST2 Oncogene; HBGF-6;

NCIt definition : Human FGF6 wild-type allele is located within 12p13 and is approximately 11 kb in length. This allele, which encodes fibroblast growth factor 6 protein, is involved in mitogenesis and angiogenesis. Aberrant allelic activity was capable of oncogenic transforming activity when transfected into mammalian cells.;

NCIt note : Distal to VWF, human Fibroblast Growth Factor 6 Gene (FGF family) at 12p13 encodes a product that exhibits strong mitogenic/angiogenic properties likely expressed by cells with platelet/megakaryocytic differentiation potential. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.;

GenBank Accession Number : NM_020996;

Details

Origin ID

C51501;

UMLS CUI

C1705578;

OMIM relation
- Fibroblast growth factor 6 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 12: 4425041-4413569 [NCIt concept]
gene_in_chromosomal_location
- 12p13 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
gene_plays_role_in_process
- Angiogenic Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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