" /> FGF3 wt Allele - CISMeF





Preferred Label : FGF3 wt Allele;

NCIt synonyms : Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site (V-Int-2) Oncogene Homolog) Gene; MMTV Integration Site Gene 2; INT2; INT-2; Oncogene INT2; HBGF-3; Murine Mammary Tumor Virus Integration Site 2, Mouse Gene; V-INT2 Murine Mammary Tumor Virus Integration Site Oncogene Homolog Gene; Murine Mammary Tumor Virus Integration Site 2 Gene; Fibroblast Growth Factor 3 wt Allele;

NCIt definition : Human FGF3 wild-type allele is located within 11q13 and is approximately 9 kb in length. This allele, which encodes fibroblast growth factor 3 protein, plays a role in cellular growth and signal transduction. Frequent amplification of this allele has been found in human tumors, which may be important for neoplastic transformation and tumor progression.;

NCIt note : Human Fibroblast Growth Factor 3 Gene (FGF family) at 11q13 contains three exons having a distinct pattern of expression throughout vertebrate development. In mouse, FGF3 signals induction of the otic vesicle; rhombencephalic transcripts are detected when inner ear induction occurs. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.;

GenBank Accession Number : NM_005247;

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03/06/2024


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