Interleukin-1 Receptor Accessory Protein

Preferred Label : Interleukin-1 Receptor Accessory Protein;

NCIt synonyms : Interleukin 1 Receptor Accessory Protein; IL-1R-3; IL1RAP; Interleukin-1 Receptor 3; EC 3.2.2.6; IL-1RAcP; IL-1R3; IL-1 Receptor Accessory Protein;

NCIt definition : Interleukin-1 receptor accessory protein (570 aa, 65 kDa) is encoded by the human IL1RAP gene. This protein is involved in cyclic ADP-ribose synthesis and interleukin-1 receptor coreceptor activity.;

NCIt note : Interleukin-1 receptor accessory protein is expressed as four isoforms produced by alternative splicing. Two isoforms are transmembrane proteins and two are secreted proteins. (UniProt);

Details

Origin ID

C178638;

UMLS CUI

C1700957;

Automatic exact mappings (from CISMeF team)
- Interleukin 1 receptor accessory protein [OMIM gene]
- Interleukin-1 receptor accessory protein [MeSH concept]
- interleukin 1 receptor accessory protein [HGNC gene]
- interleukin-1 receptor accessory protein [MeSH Descriptor]
OMIM relation
- Interleukin 1 receptor accessory protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL1RAP protein, human [MeSH Supplementary Concept]
- IL1RAP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- IL1RAP Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Immunoglobulin Family Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
is_target
- Nidanilimab [NCIt concept]

Keyword's position in hierarchy(ies) :

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