" /> Autologous Anti-IL-1RAP CAR T-cells CCTx-001 - CISMeF





Preferred Label : Autologous Anti-IL-1RAP CAR T-cells CCTx-001;

NCIt synonyms : Autologous Anti-IL-1RAP CAR T Cells CCTx-001; Autologous Anti-IL-1RAP CAR-T Cells CCTx-001;

NCIt definition : A preparation of autologous CD4 and CD8 T-lymphocytes that have been transduced to express a chimeric antigen receptor (CAR) consisting of an anti-interleukin-1 receptor accessory protein (IL-1RAP; IL-1 receptor 3; IL-1R3) single chain variable fragment (scFv) coupled to the hinge domain of human immunoglobulin G1 (IgG1), the co-stimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-IL-1RAP CAR T-cells CCTx-001 specifically recognize and kill IL-1RAP-expressing tumor cells. IL-1RAP, a transmembrane glycoprotein, is highly expressed on leukemic cells but not on healthy hematopoietic stem and progenitor cells (HSPCs); its expression has been correlated with poor prognosis.;

Molecule name : CCTx 001; CCTx-001;

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17/06/2025


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