interleukin-1 receptor accessory protein

Preferred Label : interleukin-1 receptor accessory protein;

MeSH definition : A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.;

MeSH synonym : il-1racp; interleukin 1 receptor accessory protein;

MeSH annotation : Do not confuse with INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN;

Is substance : O;

Details

Origin ID

D053577;

UMLS CUI

C0531041;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Indexing information
- rilonacept [MeSH Supplementary Concept]
Record concept(s)
- Interleukin-1 receptor accessory protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- IL1RAP protein, human [MeSH Supplementary Concept]
- IL1RAPL1 protein, human [MeSH Supplementary Concept]
- IL1RAPL1 protein, rat [MeSH Supplementary Concept]
- IL1RAPL2 protein, human [MeSH Supplementary Concept]
- Il1rap protein, mouse [MeSH Supplementary Concept]
- Il1rap protein, rat [MeSH Supplementary Concept]
- interleukin-1 receptor accessory protein-like 1, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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