" /> MECOM wt Allele - CISMeF





Preferred Label : MECOM wt Allele;

NCIt synonyms : Myelodysplasia Syndrome 1 Gene; MGC163392; MGC97004; Ecotropic Viral Integration Site 1 Gene; MDS1-EVI1; MDS1; PRDM3; EVI1; MDS1 and EVI1 Complex Locus wt Allele; EVI1 wt Allele; RUSAT2; PR Domain 3 Gene; KMT8E; Myeloid Leukemia-Associated Gene EVI1, Mouse, Homolog of Gene;

NCIt definition : Human MECOM wild-type allele is located in the vicinity of 3q26.2 and is approximately 580 kb in length. This allele, which encodes histone-lysine N-methyltransferase MECOM protein, is involved in DNA binding, transcription factor activity and histone methylation. Mutation of the gene is associated with radioulnar synostosis with amegakaryocytic thrombocytopenia-2. Chromosomal translocations involving this gene are associated with leukemogenesis.;

GenBank Accession Number : S82592;

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12/05/2024


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