Preferred Label : FGF9 wt Allele;
NCIt synonyms : GAF; HBFG-9; SYNS3; Fibroblast Growth Factor 9 wt Allele; Fibroblast Growth Factor 9 (Glia-Activating Factor) Gene; FGF-9;
NCIt definition : Human FGF9 wild-type allele is located within 13q11-q12 and is approximately 30 kb
in length. This allele, which encodes fibroblast growth factor 9 protein, is involved
in cellular growth, proliferation, glial cell development, and the negative regulation
of apoptosis.;
NCIt note : Expressed by glia and neurons, human FGF9 Gene (FGF family) encodes 208-aa 23-kDa
(precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9, with glial
growth-stimulating effects and likely involved in glial cell growth and differentiation,
gliosis, and differentiation or survival of neuronal cells. Expression may be dependent
on Sonic hedgehog signaling. Mice lacking the homolog gene displayed a male-to-female
sex reversal phenotype, which suggested a role in testicular embryogenesis.;
GenBank Accession Number : NM_002010;
Origin ID : C51504;
UMLS CUI : C1708018;
OMIM relation
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
