" /> FGF5 wt Allele - CISMeF





Preferred Label : FGF5 wt Allele;

NCIt synonyms : Fibroblast Growth Factor 5 wt Allele; TCMGLY; HBGF-5; Smag-82;

NCIt definition : Human FGF5 wild-type allele is located within 4q21 and is approximately 24 kb in length. This allele, which encodes fibroblast growth factor 5 protein, is involved in cellular growth and proliferation. Aberrant allelic activity was capable of oncogenic transforming activity when transfected into mammalian cells.;

NCIt note : Expressed in neonatal brain, human Fibroblast Growth Factor 5 Gene (FGF family) at 4q21 has a three-exon structure typical for this family. Two isoforms are produced by alternative splicing. This gene is an oncogene, and targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.;

GenBank Accession Number : NM_004464;

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20/05/2024


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