Lung cancer - CISMeF

Preferred Label : Lung cancer;

Type : Phenotype, molecular basis known;

Included titles and symbols : Alveolar cell carcinoma; Adenocarcinoma of lung; Nonsmall cell lung cancer; Lung cancer, protection against;

Description : Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (Herbst et al., 2008).;

Inheritance : Somatic mutation; Autosomal dominant;

Molecular basis : Susceptibility conferred by mutation in the epidermal growth factor receptor gene (EGFR, 131550.0006);

Neoplasia : Alveolar cell carcinoma; Adenocarcinoma of lung; Nonsmall cell lung cancer;

Prefixed ID : #211980;

Details

Origin ID

211980;

UMLS CUI

C0242379;

Automatic exact mappings (from CISMeF team)
- Adenocarcinoma lung [MedDRA LLT]
- Adenocarcinoma of Lung [MeSH Descriptor]
- Adenocarcinoma of bronchus or lung [ICD-11 Subcategory]
- Adenocarcinoma of lung [MedDRA LLT]
- Adenocarcinoma of lung (disorder) [SNOMED CT concept]
- Alveolar cell carcinoma [HPO term]
- Alveolar cell carcinoma [MedDRA LLT]
- Bronchiolo-alveolar adenocarcinoma (morphologic abnormality) [SNOMED CT concept]
- Lepidic adenocarcinoma [ICD-11 Extension code]
- Lung Adenocarcinoma [NCIt concept]
- Lung Non-Small Cell Carcinoma [NCIt concept]
- Lung adenocarcinoma [MedDRA Preferred Term]
- Lung cancer [HPMULTI term]
- Malignant neoplasms of bronchus or lung [ICD-11 Category]
- NCI CTEP SDC Non-Small Cell Lung Cancer Sub-Category Terminology [NCIt concept]
- Neoplasm of the lung [HPO term]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Non-small cell lung cancer [MedDRA Preferred Term]
- Non-small cell lung cancer (disorder) [SNOMED CT concept]
- adenocarcinoma of lung [MeSH concept]
- adenocarcinoma, bronchiolo-alveolar [MeSH Descriptor]
- carcinoma, non-small-cell lung [MeSH Descriptor]
- lung adenocarcinoma [DO Concept]
- lung carcinoma [DO Concept]
- lung neoplasms [MeSH Descriptor]
- lung non-small cell carcinoma [DO Concept]
- malignant neoplasm bronchus/lung [ICPC-2 Rubric]
Currated CISMeF NLP mapping
- Cancer of lung [MedDRA LLT]
- Lung Carcinoma [NCIt concept]
- Lung cancer [MedDRA LLT]
- Lung cancer [PASCAL descriptor]
- Lung cancer NOS [MedDRA LLT]
- Lung neoplasm malignant [MedDRA Preferred Term]
- Malignant Lung Neoplasm [NCIt concept]
- Malignant tumor of lung (disorder) [SNOMED CT concept]
- Primary malignant neoplasm of lung (disorder) [SNOMED CT concept]
- lung cancer [Disease (Nov.)]
- lung cancer [MedlinePlus Topic]
- lung cancer [MeSH concept]
- lung cancer [DO Concept]
- lung cancer [Radlex concept]
- malignant neoplasm of lung, nos [SNOMED Notion]
DO Cross reference
- lung cancer [DO Concept]
Genes related to phenotype
- B-raf protooncogene, serine/threonine kinase [OMIM gene]
- Caspase 8, apoptosis-related cysteine protease [OMIM gene]
- Epidermal growth factor receptor [OMIM gene]
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
- Ercc excision repair 6, chromatin remodeling factor [OMIM gene]
- Fas ligand [OMIM gene]
- Interferon regulatory factor 1 [OMIM gene]
- Kras protooncogene, gtpase [OMIM gene]
- Mitogen-activated protein kinase kinase kinase 8 [OMIM gene]
- Parkin rbr e3 ubiquitin protein ligase [OMIM gene]
- Phosphatidylinositol 3-kinase, catalytic, alpha [OMIM gene]
- Protein phosphatase 2, structural/regulatory subunit a, beta [OMIM gene]
- Solute carrier family 22 (organic cation transporter), member 18 [OMIM gene]
HPO term(s)
- Alveolar cell carcinoma [HPO term]
- Autosomal dominant inheritance [HPO term]
- Lung adenocarcinoma [HPO term]
- Non-small cell lung carcinoma [HPO term]
- Somatic mutation [HPO term]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Cancer of lung [MedDRA LLT]
- Carcinoma lung [MedDRA LLT]
- Carcinoma of lung [MedDRA LLT]
- Lung Carcinoma [NCIt concept]
- Lung cancer [MedDRA LLT]
- Lung cancer NOS [MedDRA LLT]
- Lung carcinoma [MedDRA LLT]
- Lung neoplasm malignant [MedDRA Preferred Term]
- Malignant Lung Neoplasm [NCIt concept]
- Malignant tumor of lung (disorder) [SNOMED CT concept]
- PULMONARY CARCINOMA [WHO-ART Preferred Term]
- Pulmonary carcinoma [MedDRA LLT]
- lung cancer [MeSH concept]
- lung cancer [MedlinePlus Topic]
- lung carcinoma [DO Concept]
- malignant neoplasm of lung, nos [SNOMED Notion]
Validated automatic mappings to BTNT
- Lung adenocarcinoma [HPO term]
- Non-small cell lung carcinoma [HPO term]
- bronchioloalveolar adenocarcinoma [Disease (Nov.)]
- lung adenocarcinoma [Disease (Nov.)]
Validated automatic mappings to NTBT
- non small cell lung cancer [Disease (Nov.)]

Keyword's position in hierarchy(ies) :

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