Transcription Factor E2F3

Preferred Label : Transcription Factor E2F3;

NCIt synonyms : E2F-3;

NCIt definition : Transcription factor E2F3 (465 aa, 49 kDa) is encoded by the human E2F3 gene. This protein is involved in the modulation of both transcription and the cell cycle.;

NCIt note : Transcription factor E2F3 binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. (UniProt);

Details

Origin ID

C96006;

UMLS CUI

C1504752;

Automatic exact mappings (from CISMeF team)
- E2F3 transcription factor [MeSH concept]
- E2f transcription factor 3 [OMIM gene]
- e2f3 transcription factor [MeSH Descriptor]
OMIM relation
- E2f transcription factor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- E2F3 protein, human [MeSH concept]
- E2F3 protein, human [MeSH Supplementary Concept]
- E2F3 transcription factor [MeSH concept]
- e2f3 transcription factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- E2F3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- E2F Transcription Factor Family [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Bladder Cancer Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- G1 Phase Process [NCIt concept]
- G2 Phase Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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