FHIT wt Allele

Preferred Label : FHIT wt Allele;

NCIt synonyms : Fragile Histidine Triad wt Allele; FRA3B;

NCIt definition : Human FHIT wild-type allele is located in the vicinity of 3p14.2 and is approximately 1499 kb in length. This allele, which encodes bis(5'-adenosyl)-triphosphatase protein, is involved in the hydrolysis of P1-P3-bis(5'-adenosyl) triphosphate. FHIT gene dysfunction is associated with human cancers including carcinomas of the cervix, esophageus, lung, kidney, and stomach.;

NCIt note : Tumor Suppressor Gene;

GenBank Accession Number : NM_002012;

Details

Origin ID

C49384;

UMLS CUI

C1708020;

OMIM relation
- Fragile histidine triad diadenosine triphosphatase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_abnormality
- FHIT Gene Inactivation [NCIt concept]
gene_has_physical_location
- 3: 61212164-59712987 [NCIt concept]
gene_in_chromosomal_location
- 3p14.2 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Cervical Carcinoma [NCIt concept]
gene_is_element_in_pathway
- Purine Metabolism Pathway [NCIt concept]
gene_plays_role_in_process
- Hydrolysis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients