Betacellulin - CISMeF

Preferred Label : Betacellulin;

NCIt synonyms : Beta-Cellulin; Beta Cellulin; BTC;

NCIt definition : Betacellulin (80 aa, 9 kDa) is encoded by the human BTC gene. This protein is involved in epidermal growth factor receptor family signaling pathways.;

NCIt note : The active form of the growth factor, called betacellulin, is produced by proteolytic cleavage that removes 67 amino acids from the C-terminus of probetacellulin. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt); Betacellulin is a member of the EGF family of growth factors and a potent mitogen for retinal pigment epithelia and vascular smooth muscle cells. Betacellulin effects are mediated by the EGF receptor and related receptors. (UniProt);

Details

Origin ID

C20432;

UMLS CUI

C3884533;

Automatic exact mappings (from CISMeF team)
- Betacellulin [MeSH Descriptor]
- Betacellulin [MeSH concept]
- Betacellulin [OMIM gene]
- betacellulin [HGNC gene]
OMIM relation
- Betacellulin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BTC protein, human [MeSH concept]
- BTC protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- BTC Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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